Foundations of cellular therapies

In reviewing cellular therapies, the CCMO regularly encounters the lack of a clear foundation of the proposed use of the therapy. Sometimes this causes the rejection of a research proposal. To address this issue, a discussion in more general terms was conducted with the research field. In this consultation it has been concluded that in research with cellular therapies, a clear hypothesis about a presumed mechanism must be provided for each study. The study should aim to test this hypothesis. All choices made, such as cells of autologous or allogenic origin and dosage, must be substantiated in the research file. For more information, see the Note Foundations of cellular therapies (in Dutch).